Theodore C Friedman Selected Research

Nicotine

1/2021	Unhealthy Lifestyle and Gut Dysbiosis: A Better Understanding of the Effects of Poor Diet and Nicotine on the Intestinal Microbiome.
1/2021	Adverse effects of fetal exposure of electronic-cigarettes and high-fat diet on male neonatal hearts.
1/2020	Electronic cigarettes cause alteration in cardiac structure and function in diet-induced obese mice.
10/2019	A mouse model for chronic intermittent electronic cigarette exposure exhibits nicotine pharmacokinetics resembling human vapers.
1/2019	Chronic intermittent electronic cigarette exposure induces cardiac dysfunction and atherosclerosis in apolipoprotein-E knockout mice.
1/2019	Hepatic DNA Damage Induced by Electronic Cigarette Exposure Is Associated With the Modulation of NAD+/PARP1/SIRT1 Axis.
1/2018	α7-Nicotinic Acetylcholine Receptor Agonist Ameliorates Nicotine Plus High-Fat Diet-Induced Hepatic Steatosis in Male Mice by Inhibiting Oxidative Stress and Stimulating AMPK Signaling.
1/2017	Connection of Nicotine to Diet-Induced Obesity and Non-Alcoholic Fatty Liver Disease: Cellular and Mechanistic Insights.
1/2017	Nicotine plus a high-fat diet triggers cardiomyocyte apoptosis.
3/2014	Nicotine in combination with a high-fat diet causes intramyocellular mitochondrial abnormalities in male mice.

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Theodore C Friedman Research Topics

Disease

9	Insulin Resistance 11/2019 - 06/2003
9	Body Weight (Weight, Body) 10/2019 - 06/2003
7	Obesity 01/2020 - 06/2003
7	Type 2 Diabetes Mellitus (MODY) 12/2018 - 01/2005
5	Metabolic Syndrome (Dysmetabolic Syndrome X) 11/2019 - 04/2013
5	Weight Gain 05/2016 - 08/2008
5	Hyperglycemia 04/2013 - 06/2003
4	Non-alcoholic Fatty Liver Disease 01/2021 - 01/2017
3	Inflammation (Inflammations) 01/2019 - 01/2004
2	Cushing Syndrome 03/2021 - 06/2018
2	Abdominal Obesity 11/2019 - 03/2014
2	Prediabetic State (Prediabetes) 02/2013 - 11/2011
2	Weight Loss (Weight Reduction) 03/2012 - 06/2003
2	Hypothyroidism 01/2007 - 01/2005
1	Fibrosis (Cirrhosis) 04/2021
1	Pituitary ACTH Hypersecretion 03/2021
1	Maternal Obesity 01/2021
1	Dysbiosis 01/2021
1	Metabolic Diseases (Metabolic Disease) 01/2021
1	Chronic Hepatitis B 01/2021
1	Atherosclerosis 01/2019
1	Cardiomyopathies (Cardiomyopathy) 01/2017
1	Heart Failure 01/2017
1	Endocrine System Diseases (Endocrine Diseases) 07/2012
1	Marijuana Use 01/2012
1	Pain (Aches) 01/2011
1	Opioid-Related Disorders (Opiate Addiction) 02/2010
1	Hypogonadism (Hypergonadotropic Hypogonadism) 02/2010
1	Chronic Pain 02/2010
1	Psychotic Disorders (Schizoaffective Disorder) 01/2010
1	Schizophrenia (Dementia Praecox) 01/2010
1	Hyperthyroidism 01/2005
1	Starvation 08/2004
1	Chronic Renal Insufficiency 07/2002
1	Secondary Hyperparathyroidism 07/2002

Drug/Important Bio-Agent (IBA)

14	Nicotine FDA Link 01/2021 - 03/2012
10	GlucocorticoidsIBA 03/2021 - 06/2003
5	Messenger RNA (mRNA)IBA 03/2014 - 01/2005
4	Hormones (Hormone)IBA 03/2021 - 07/2002
4	Vitamin D FDA LinkGeneric 02/2013 - 07/2002
3	CotinineIBA 01/2020 - 01/2017
3	Glucose (Dextrose)FDA LinkGeneric 11/2019 - 01/2012
3	ApolipoproteinsIBA 10/2019 - 01/2019
3	Apolipoproteins E (ApoE)IBA 10/2019 - 01/2019
3	Insulin (Novolin)FDA Link 11/2015 - 08/2008
3	Oxidoreductases (Dehydrogenase)IBA 01/2015 - 04/2013
3	Opioid Analgesics (Opioids)IBA 01/2013 - 02/2010
3	Glucocorticoid Receptors (Glucocorticoid Receptor)IBA 08/2008 - 01/2005
3	11-beta-Hydroxysteroid Dehydrogenase Type 1IBA 08/2008 - 06/2003
2	LipidsIBA 01/2017 - 12/2012
2	galactose-6-phosphate dehydrogenaseIBA 01/2015 - 08/2008
2	CorticosteroneIBA 03/2014 - 06/2003
2	Proteins (Proteins, Gene)FDA Link 11/2006 - 08/2004
2	LeptinIBA 08/2004 - 06/2003
1	Dronabinol (THC)FDA LinkGeneric 04/2021
1	MineralocorticoidsIBA 03/2021
1	Transferrin (beta 2 Transferrin)IBA 01/2021
1	Blood Glucose (Blood Sugar)IBA 11/2019
1	AerosolsIBA 10/2019
1	Dexamethasone (Maxidex)FDA LinkGeneric 06/2018
1	Hydrocortisone (Cortisol)FDA LinkGeneric 06/2018
1	Tobacco Smoke Pollution (Passive Smoking)IBA 01/2017
1	Pioglitazone (Actos)FDA Link 11/2015
1	Metformin (Glucophage)FDA LinkGeneric 11/2015
1	Small Interfering RNA (siRNA)IBA 01/2015
1	Lipase (Acid Lipase)FDA Link 01/2015
1	NADP (NADPH)IBA 03/2014
1	AMP-Activated Protein KinasesIBA 03/2014
1	EnzymesIBA 04/2013
1	Morphine (MS Contin)FDA LinkGeneric 01/2013
1	Adenosine Monophosphate (AMP)IBA 01/2013
1	Nicotinic Receptors (Nicotinic Acetylcholine Receptor)IBA 03/2012
1	MecamylamineIBA 03/2012
1	Varenicline (Chantix)FDA Link 03/2012
1	C-Reactive ProteinIBA 01/2012
1	CholesterolIBA 01/2012
1	Triglycerides (Triacylglycerol)IBA 01/2012
1	HDL LipoproteinsIBA 01/2012
1	Pituitary HormonesIBA 02/2010
1	Dizocilpine Maleate (Dizocilpine)IBA 01/2010
1	N-Methyl-D-Aspartate Receptors (NMDA Receptors)IBA 01/2010
1	pro-thyrotropin releasing hormoneIBA 01/2007
1	Proprotein Convertases (Pro-Opiomelanocortin Converting Enzyme)IBA 01/2007
1	LigandsIBA 11/2006
1	T0901317IBA 11/2006
1	Thyroxine (Levothyroxine)FDA LinkGeneric 01/2005
1	Mifepristone (RU 486)FDA Link 01/2005
1	Streptozocin (Streptozotocin)FDA Link 06/2003

Therapy/Procedure

3	Therapeutics 01/2021 - 07/2012
3	Injections 01/2017 - 12/2012
1	Adrenalectomy 03/2021
1	Intraperitoneal Injections 01/2018
1	Analgesia 01/2011
1	Craniotomy 01/2004